2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-124996
    (Rac)-ZLc-002 98.96%
    (Rac)-ZLc-002, an inhibitor of nNOS interaction with nitric oxide synthase 1 adaptor protein (NOS1AP), suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with Paclitaxel (HY-B0015) to reduce tumor cell viability.
    (Rac)-ZLc-002
  • HY-125043
    SKF-75670 hydrobromide 62717-63-9 99.83%
    SKF-75670 hydrochloride is a Dopamine D1 receptor partial agonist. SKF-75670 hydrochloride is also a Cocaine antagonist.
    SKF-75670 hydrobromide
  • HY-125095
    Yonkenafil hydrochloride 804519-64-0 99.43%
    Yonkenafil (Tunodafil) hydrochloride, a novel phosphodiesterase 5 (PDE5) inhibitor, is effective in reducing cerebral infarction, neurological deficits, edema, and neuronal damage in the infarcted area. Yonkenafil (Tunodafil) hydrochloride may improve cognitive function by modulating neurogenesis and has a potential therapeutic effect on Alzheimer's disease.
    Yonkenafil hydrochloride
  • HY-125515
    Tetrahydroharmine 17019-01-1 98.00%
    Tetrahydroharmine (Leptaflorine) is A monoamine oxidase (MAO) inhibitor with a IC50 value of 74 nM for MAO-A. Tetrahydroharmine can be used in the study of neurodegenerative diseases.
    Tetrahydroharmine
  • HY-125558
    PT150 189035-07-2
    PT150 (ORG-34517) is a competitive and orally active glucocorticoid receptor antagonist. PT150 shows neuroprotective effects. PT150 has the potential for the research of Parkinson’s disease.
    PT150
  • HY-125743
    S-1 Methanandamide 157182-50-8 98.0%
    S-1 Methanandamide ((S)-Methanandamide), an Anandamide analog, is a CB1 receptor ligand with a Ki of 173 nM. S-1 Methanandamide inhibits electrically-evoked twitch response in mouse vas deferens with an IC50 value of 230 nM.
    S-1 Methanandamide
  • HY-125780
    5-Phenylhydantoin 89-24-7
    5-Phenylhydantoin is an antiepileptic compound, and has certain hypolipidemic compound.
    5-Phenylhydantoin
  • HY-125819
    Sigma-1 receptor antagonist 2 1639220-15-7 99.76%
    Sigma-1 receptor antagonist 2 is a potent and selective sigma 1 receptor (σ1 R) antagonist with Kis of 3.88 and 1288 nM for σ1 and σ2 receptor, respectively.
    Sigma-1 receptor antagonist 2
  • HY-125820
    Sigma-1 receptor antagonist 3 1639220-17-9 99.47%
    Sigma-1 receptor antagonist 3 (compound135) is a potent and selective Sigma-1 (σ1) receptor antagonist with a Ki of 1.14 nM. Sigma-1 receptor antagonist 3 inhibits Human Ether-a-go-go-Related Gene (hERG) with an IC50 of 1.54 μM. Sigma-1 receptor antagonist 3 has the potential for the neuropathic pain.
    Sigma-1 receptor antagonist 3
  • HY-125986
    GK187 1071001-50-7 ≥98.0%
    GK187 is a potent and selective Group VIA calcium-independent phospholipase A2 (GVIA iPLA2) inhibitor with an XI(50) value of 0.0001. GK187 can be used for researching various neurological disorders.
    [The XI(50) is the mole fraction of the inhibitor in the total substrate interface required to inhibit the enzyme by 50%.]
    GK187
  • HY-126025
    α-Phthalimidopropiophenone 19437-20-8 99.9%
    α-Phthalimidopropiophenone is a drug derivative.
    α-Phthalimidopropiophenone
  • HY-126043
    (R)-Mephenytoin 71140-51-7 99.58%
    (R)-Mephenytoin ((-)-Mephenytoin), the R-enantiomer of Mephenytoin. Mephenytoin is an Anticonvulsant agent.
    (R)-Mephenytoin
  • HY-126061
    1,7-Dimethyluric acid 33868-03-0 99.82%
    1,7-Dimethyluric acid is the metabolite of caffeine.
    1,7-Dimethyluric acid
  • HY-126161
    Nonabine 16985-03-8 99.95%
    Nonabine (BRL-4664), a cannabinoid, is a antiemetic agent. Nonabine activates CB1 receptor in the brainstem and enteric nervous system.
    Nonabine
  • HY-126712
    ROS tracer precursor 2153480-20-5 98.56%
    ROS tracer precursor is the precursor of [18F]ROStrace for the synthesis of ROStrace, which can be used for disease diagnosis.
    ROS tracer precursor
  • HY-126719
    R-1 Methanandamide Phosphate 649569-33-5 98.0%
    R-1 Methanandamide Phosphate is a water-soluble prodrug analog of arachidonylethanolamide (AEA). AEA is an endogenous cannabinoid compound.
    R-1 Methanandamide Phosphate
  • HY-12701A
    U-99194 maleate 234757-41-6 99.23%
    U-99194 (PNU-99194) maleate is a selective, potent dopamine D3 receptor antagonist (Ki =160 nM). U-99194 maleate inhibits the activation of D3 receptor mediated by endogenously released dopamine or exogenous D3 agonists. U-99194 maleate abrogates the IPSC-suppressive effect of the D3 agonist PD 128907 in rat hippocampal slices. U-99194 maleate significantly suppresses Nicotine (HY-127019)-induced tremor in mice. U-99194 maleate can be used for the study of dopamine D3 receptor-mediated motor disorders, particularly kinetic tremors.
    U-99194 maleate
  • HY-12707S
    Piribedil-d8 1398044-45-5 99.79%
    Piribedil-d8 is the deuterium labeled Piribedil, which is an antiparkinsonian agent.
    Piribedil-d8
  • HY-12715S
    Yohimbine-13C,d3 1261254-59-4 99.0%
    Yohimbine-13C,d3 is the 13C- and deuterium labeled Yohimbine. Yohimbine is a potent and relatively nonselective alpha 2-adrenergic receptor (AR) antagonist, with IC50 of 0.6 μM.
    Yohimbine-13C,d3
  • HY-12752S
    Alimemazine-d6 1346603-88-0 99.55%
    Alimemazine-d6 is deuterium labeled Alimemazine, which is an antihistamine.
    Alimemazine-d6
Cat. No. Product Name / Synonyms Application Reactivity